The goal of our research is to better understand the neuronal circuitry and molecular mechanisms that underlie substance use disorders, posttraumatic stress disorder, and their co-occurrence. We use rodent models of these disorders, behavioral tasks, and molecular techniques to identify the brain-behavior relationships that develop after exposure to traumatic stress and/or drugs and ways the brain changes to lead to addiction or PTSD. A major focus of our lab is on the comorbidity between PTSD and substance use disorders and exploration of the neurobiology of the reward and stress-trauma neurocircuitry.