Perrine Lab at Wayne State University

The goal of our research is to better understand the neuronal circuitry and molecular mechanisms that underlie substance use disorders, posttraumatic stress disorder, and their co-occurrence. We use rodent models of these disorders, behavioral tasks, and molecular techniques to identify the brain-behavior relationships that develop after exposure to traumatic stress and/or drugs and the ways the brain changes to lead to addiction or PTSD. A major focus of our lab is on the comorbidity between PTSD and substance use disorders and exploration of the neurobiology of the reward and stress-trauma neurocircuitry.